| oveR-2-Revo|

chinese lantern

2011-12-21T05:30:00.001-05:00

SUCH an useful tracker!!!

2011-12-20T06:41:00.000-05:00

http://www.travelineeastanglia.org.uk/ea/XSLT_DM_REQUEST

viva says..... YAY amma!

2011-11-28T05:25:00.001-05:00

New Entry to my blog!!! My new hobby as well.

CyclePath ART Work

2008-09-08T17:25:00.003-04:00

More information can be found in this link: http://www.sanger.ac.uk/Info/News-releases/2007/070620.shtml

Nish and I went biking with our friends (JY & MP) on 10,000 stripes representing the genetic code for a vital human gene - BRCA2. The stripes are in four colours representing the four different types of genetic letters that make up our DNA.

Rising moon or Maria

2006-10-05T21:50:00.000-04:00

arabic-coffee

2006-10-05T20:53:00.000-04:00

tulip02: burnt orange

2006-05-10T19:35:00.000-04:00

Hoodoos - live measure of time.

2006-05-07T23:18:00.000-04:00

Even the innocuous wind can carve a mountain, if persistent.

Athabasca Glacier

2006-05-04T22:19:00.000-04:00

I learnt that Glaciers are Waterfalls;
more appropriately Icefalls.
This one with innocent emerald tone
was scarily all ready to descend.

sulphur mountain

2006-04-30T14:13:00.000-04:00

roots in air??

2006-04-22T00:19:00.000-04:00

tulip.01

2006-04-18T22:47:00.000-04:00

BROOKLYN BOTANICAL GARDEN, NY.
When the golden day is done,
through the closing portal,
child and garden, flower and sun,
vanish all things mortal.
R.L. Stevenson

brushstrokes

2006-04-14T21:35:00.000-04:00

artefacts on

2006-04-13T21:17:00.000-04:00

This morning's surprise visitors

2006-03-30T21:59:00.000-05:00

?..>

2006-03-24T20:49:00.000-05:00

?~.
Swan formatted.

through a telescopic viewer

2006-03-21T00:40:00.000-05:00

Great cormorant-
perched on the rock.
Cold Cape Ann, MA.

glazed glass

2006-03-16T22:11:00.000-05:00

spice tones

2006-03-08T22:26:00.000-05:00

Wild red berries

2006-03-05T10:17:00.000-05:00

Beneath a bright blue sky
were deep red berries and I.
We stared at each other
for a while -

Then I caught them
with a camera shot;
and they stole a space
from my memory lot.

patterned cycles

2006-02-23T19:41:00.000-05:00

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quest: why & how

2006-02-21T21:28:00.000-05:00

It is early in the morning;
for me late into last evening.
Should catch some sleep;
before my alarm does beep.
I sink into my cozy white bed;
with thoughts that have no rest.
Where does time lay buried?
I always find myself hurried.
Questions with no answers,
naps that long to be slumbers.
This is my daily routine -
a way days end and begin.
The morning sun is bright
I refuse to see the light.
But my alarm did not fail;
Neither did my mail.
I get all dressed,
another day to be rushed.
My questions still wait,
to be addressed late tonight.

flames of white

2006-02-19T11:34:00.000-05:00

To the heart, to the heart the white petals
Quietly fall.
Memory is a little wind, and magical
The dreaming hours.
As a breath they fall, as a sigh;
Green garden hours too langorous to waken.
White leaves of blossomy tree wind-shaken;
As a breath, a sigh,
As the slow white drift
Of a butterfly.
Flower-wings falling, wings of branches
One after one at wind's droop dipping;
Then with the lift
Of the air's soft breath, in sudden avalanches
Slipping.
Quietly, quietly the June wind flings
White wings,
White petals, past the footpath flowers
Adown my dreaming hours.
At the heart, at the heart the butterfly settles.
As a breath, a sigh
Fall the petals of hours, of the white-leafed flowers
Fall the petalled wings of the butterfly.
To my heart, to my heart the white petals
Quietly fall. -Thomas Moult

Desiderata

2006-02-10T09:56:00.000-05:00

Go placidly amid the noise and haste,
and remember what peace there may be in silence.
As far as possible without surrender
be on good terms with all persons.
Speak your truth quietly and clearly;
and listen to others,
even the dull and the ignorant;
they too have their story.
Avoid loud and aggressive persons,
they are vexations to the spirit.
If you compare yourself with others,
you may become vain and bitter;
for always there will be greater and lesser persons than yourself.
Enjoy your achievements as well as your plans.
Keep interested in your own career, however humble;
it is a real possession in the changing fortunes of time.
Exercise caution in your business affairs;
for the world is full of trickery.
But let this not blind you to what virtue there is;
many persons strive for high ideals;
and everywhere life is full of heroism.
Be yourself.
Especially, do not feign affection.
Neither be cynical about love;
for in the face of all aridity and disenchantment
it is as perennial as the grass.
Take kindly the counsel of the years,
gracefully surrendering the things of youth.
Nurture strength of spirit to shield you in sudden misfortune.
But do not distress yourself with dark imaginings.
Many fears are born of fatigue and loneliness.
Beyond a wholesome discipline,
be gentle with yourself.
You are a child of the universe,
no less than the trees and the stars;
you have a right to be here.
And whether or not it is clear to you,
no doubt the universe is unfolding as it should.
Therefore be at peace with God,
whatever you conceive Him to be,
and whatever your labors and aspirations,
in the noisy confusion of life keep peace with your soul.
With all its sham, drudgery, and broken dreams,
it is still a beautiful world.
Be cheerful.
Strive to be happy.
-Max Ehrmann, Desiderata.

wax floaters on water

2006-02-05T12:10:00.000-05:00

spring in malaga

2006-02-03T00:05:00.000-05:00

Serene space in Malkajgiri

2006-01-21T18:51:00.000-05:00

Just as a solid rock is not shaken by the storm,
even so the wise are not affected by praise or blame.
Dhammapada 81.

KAMBI-MATHAAPPU....

2006-01-16T18:22:00.000-05:00

Taken during my visit to India. more pics to follow.....

Kinetochores-Microtubules-chromosomes

2005-10-10T00:19:00.000-04:00

Cells divide throughout life to grow and renew tissues. During cell division, the genetic material (chromosomes) should be equally and accurately separated between the two daughter cells. Each human cell has 23 pairs of chromosomes. Errors in chromosome separation are often found in tumours.
My interest is to understand the mechanism by which chromosomes are captured by microtubules (imagine ropes capturing a bulky mass) and separated into two equal sets.
How do microtubules pull and push chromosomes during chromosome separation?
How is biochemical energy translated into mechanical movement of chromosomes?
These are the two fundamental and fascinating questions of my research work.
Background:
Microtubules (in green) capture chromosomes (in blue) in a stochastic manner via large multi-protein structures called ‘kinetochores’ (in red). Each human kinetochore attaches to 20-40 microtubules.

Microscopists had known for nearly 50 years that even a single incorrectly attached kinetochore is sufficient to pause the separation of all chromosomes within a cell. This way the cell makes sure that chromosomes do not permaturely separate before all of them are correctly attached to microtubules from opposite sides of the spindle. The molecular players essential for this pivotal error-check mechanism were revealed using yeast genetics. These are evolutionarily conserved 'checkpoint proteins' present in all cells from yeasts to humans. But the precise biochemical nature of the signal monitored by checkpoint proteins is not known. This is a puzzling and one of the hot questions in the field.

Another interesting question and my favourite one is the following: Since microtubule capture is stochastic, there must be error correcting mechanisms- i.e., to stablize correct attachments and to selectively lose wrong ones. Very few clues exist to describe this mysterious process as well.

To unravel how the proteins of the kinetochore signal incorrect attachment and coordinate mechanical movements, we first need to understand how the proteins of the kinetochore interact with microtubules.
I employ quantitative cell-biology assays to follow the dynamic movements of chromosomes during mitosis. I use molecular tools to analyse how the proteins of the kinetochore influence chromosome movement.
For more information on results, wait to see my paper or poster at ASCB :)

Glass pumpkins

2005-09-25T01:00:00.000-04:00

MIT PUMPKIN FEST

Franklin zoo

2005-09-23T00:26:00.000-04:00

Across: purple flower

2005-09-17T10:12:00.000-04:00

we have just started on this 49 squarefeet of crossword puzzle.

Leonardo Da Vinci: Time stays long enough for anyone who will use it.

2005-09-15T14:43:00.000-04:00

Near the bike path by Charles river

3D butterflies

2005-09-12T23:25:00.000-04:00

Emily brought them from Canada and they are now on my wall.

soon after rain

2005-09-10T11:25:00.000-04:00

Knowledge and timber shouldn't be much used, till they are seasoned -HOLMES

2005-08-30T14:32:00.000-04:00

Shot in the Morning ....

:)

Claremont boulevard

2005-08-25T22:53:00.000-04:00

******

Capecod coast

2005-08-25T19:51:00.000-04:00

By the Nobska lighthouse

The question returned -
is everything a drift - predestined?
or they choices that we get to do?
what if I stop now - right now...
and choose to leave behind
the burdering have-to-dos
and pick only those pieces
that I dearly would like to do ?

Woods Hole in Summer

2005-08-24T20:14:00.000-04:00

Note to myself: swish-swish of water against the boats and the soft fragrance of rose made it all the more beautiful

Misty morning

2005-08-21T19:16:00.000-04:00

On my walk towards MBL @7AM

WWW - Wet White Web

2005-08-20T20:13:00.000-04:00

I loved watching this mix of lightness and weight together...reminded me the title of a book 'the unbearable feeling of lightness'.

By an old church

2005-08-07T13:40:00.000-04:00

The old believe everything; the middle-aged suspect everything; the young know everything.- O Wilde

Resting Seals

2005-06-30T11:39:00.000-04:00

LaJolla Cove in Sandiego

2005-06-30T11:37:00.000-04:00

Salk institute campus

5.30AM ON 5.30 OF 2005

2005-05-30T19:08:00.000-04:00

Post starwars from Tang

With Lava and Sree

2005-05-30T19:07:00.000-04:00

movie-marathon

Together in lab

2005-05-27T16:35:00.000-04:00

Fluffy and Tubby for Caroline

2005-05-26T22:37:00.000-04:00

The indestructible bleach drinker

2005-05-25T01:09:00.000-04:00

Aha! KINETOCHORES in red on the blue human chromosomes

2005-05-25T00:44:00.000-04:00

introducing canon_elph